Septic Shock
Conditions
Interventions
Group A: Midazolam group:The first dose was 0.1~0.3 mg/kg intravenous pumping (10-15 min), and the maintenance dose was 1-5 µg/kg/min intravenous pumping
Group B: Dexmedetomidine group:The first dose was 0.5~1.0 µg/kg intravenous pumping (10-15 min), and the maintenance dose was 0.3-0.6 µg/kg/h intravenous pumping
Sponsors
Women and Children's Hospital of Ningbo University
Eligibility
Sex/Gender
All
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: 1. Collected from January 2024 to December 2024 who were admitted to the PICU of our hospital and diagnosed with septic shock, aged 28 days ~ 18 years old, and gender is not limited. 2. There is a "period of instability" of organ function that requires moderate to severe sedation strategies (such as severe human-machine confrontation, acute respiratory distress syndrome in children, severe head injury and increased intracranial pressure, status epilepticus, before the use of neuromuscular blocking agents, etc.). 3. The diagnostic criteria for septic shock refer to the International Consensus Conference on Sepsis in Children: Definition of Sepsis and Organ Dysfunction in Children (2005 edition). 4. Moderate to severe sedation in the bispectral index (BIS). During the sedation period, all children met the RASS score of -3~-4, and the BIS index was 40~80.
Exclusion criteria
Exclusion criteria: 1. Tumors and neoplasia lesions; 2. Autoimmune diseases; 3. Inborn metabolic diseases; 4. Genetic and chromosomal lesions; 5. Tuberculosis; 6. Parasitic diseases; 7. Liver and kidney failure; 8. Children with immunosuppressive drugs and adverse drug reactions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immune cytokine levels;Lymphocyte subsets; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality;Hemodynamic parameters; | — |
Countries
China
Contacts
Public ContactYao Zheng
Women and Children's Hospital of Ningbo University
Outcome results
None listed