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A single-center retrospective study of the pattern of immune reconstitution after allogeneic hematopoietic stem cell transplantation for aplastic anemia

A single-center retrospective study of the pattern of immune reconstitution after allogeneic hematopoietic stem cell transplantation for aplastic anemia

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500105589
Enrollment
Unknown
Registered
2025-07-07
Start date
2025-01-01
Completion date
Unknown
Last updated
2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aplastic Anemia

Interventions

Continuous enrollment (Aplastic Anemia Transplantation Group):none

Sponsors

The First Affiliated Hospital of Zhejiang University of Chinese Medicine (Zhejiang Provincial Hospital of Chinese Medicine)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) met the diagnostic criteria for aplastic anemia; (2) voluntarily chose hematopoietic stem cell transplantation for treatment; (3) did not have severe organ dysfunction or active infections.

Exclusion criteria

Exclusion criteria: (1) have congenital bone marrow failure, including Fanconi anemia (FA) and congenital dyskeratosis (DKC); (2) have other or secondary conditions of total blood cell reduction, such as myelodysplastic syndromes (MDS) and hairy cell leukemia (HCL); (3) have incomplete follow-up information.

Design outcomes

Primary

MeasureTime frame
TCR diversity;TCR clonality;other opportunistic infections;

Secondary

MeasureTime frame
T lymphocyte subset analysis;cytomegalovirus;Epstein-Barr virus;Overall Survival, OS;event free survival,EFS;

Countries

China

Contacts

Public ContactHu Huijin

The First Affiliated Hospital of Zhejiang University of Chinese Medicine (Zhejiang Provincial Hospital of Chinese Medicine)

huhuijin12@sina.com+86 188 6876 0207

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026