Acute Respiratory Distress Syndrome
Conditions
Interventions
Observation group:Closed suctioning
Control group:Open suctioning
Sponsors
The Third Medical Center of Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.ARDS patients diagnosed according to the Berlin Definition, who meet the following diagnostic criteria: (1)Onset time: Time from known clinical injury and new or worsening respiratory symptoms to meeting the diagnostic criteria, =5 cmH2O,2 00 mmHg=5 cmH2O, 100 mmHg=5 cmH2O, PaO2/FiO210^7cfu/ml 2)Criteria for identifying colonizing bacteria: Positive sputum culture and meeting three of the following conditions: a. The diagnosis of lower respiratory tract infection is not sufficient b. The diagnosis of lower respiratory tract infection is clear but treatment is ineffective based on the results of antibiotic susceptibility testing c. Negative observation of immunopathological phenomena in sputum d. The concentration of bacteria isolated in sputum culture is between 10^3cfu/ml and 10^7cfu/ml 2.PEEP level: 5<=PEEP<10cmH2O 3.18 years<=age<=85 years and the patient has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.PEEP>=10cmH2O or PEEP85 years 3.Pregnant women, patients with implanted cardiac pacemakers, patients with chest trauma or skin lesions that restrict the placement of chest straps, patients with pneumothorax and patients in the terminal stage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Systolic blood pressure;Cardiac output;Central venous pressure;Tidal volume;Minute ventilation;?EELI;Plateau pressure;Mean airway pressure;Pulse oximetry saturation;Partial pressure of oxygen in arterial blood;PaO2/FiO2;Diastolic blood pressure;Cardiac index;Pulmonary artery diameter;Driving pressure;Static respiratory system compliance;Partial pressure of carbon dioxide in arterial blood; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pathogen results;Rate of multidrug-resistant pathogens;Antibiotic usage;Nebulization;Continuous Renal Replacement Therapy;Mechanical ventilation duration ;ICU length of stay;Clinical outcome; | — |
Countries
China
Contacts
Public ContactYang Jun
The Third Medical Center of Chinese PLA General Hospital
Outcome results
None listed