Effects of donated breast milk on the intestinal microbiota and metabolites of premature infants through 16S rRNA technology and metabolomics

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500105584

Enrollment

Unknown

Registered

2025-07-07

Start date

2021-11-20

Completion date

Unknown

Last updated

2025-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intestinal microbiota and metabolites of premature infants

Interventions

formula milk group:Formula milk feeding

donor breast milk group:donor breast milk feeding

Mother's own breast milk group:Mother's own breast feeding

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. All cases were admitted by the guidelines of the American Academy of Pediatrics (AAP) . 2. Had gestational age between 28 weeks and less than 37 weeks. 3. Were admitted to the neonatal department upon birth. 4. Breastfeeding was initiated within 24 hours after admission, and there were no obvious symptoms such as vomiting, abdominal distension, or severe retention that indicated feeding intolerance.

Exclusion criteria

Exclusion criteria: 1. Severe heart, liver, or kidney dysfunction; 2. Congenital malformations; 3. Congenital genetic, metabolic, or chromosomal disorders; 4. Those who use probiotics.

Design outcomes

Primary

Measure	Time frame
short chain fatty acid;metabolites;intestinal flora;	—

Countries

China

Contacts

Public ContactFei Yang

Hangzhou Women's Hospital

370257475@qq.com+86 13732261447

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026