Sepsis associated liver injury
Conditions
Interventions
Sepsis liver injury group:Nnone
Sepsis group (sepsis non-liver injury group):None
Sponsors
Department of Intensive Care Medicine, Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with sepsis according to the sepsis-3 criteria: Infection or highly suspected infection; And ?SOFA score >= 2 points; 2.Patients diagnosed with liver injury according to the expert consensus on the diagnosis and treatment of acute liver injury in adults: Serum total bilirubin or alanine aminotransferase >= 2 upper limits of normal; 3. Aged >= 18 years; 4.Informed consent, voluntary participation, and signed informed consent form for the study process and purpose.
Exclusion criteria
Exclusion criteria: 1.Chronic liver disease or acute exacerbation of chronic liver function disorder; 2.Drug-induced liver injury; 3.History of liver transplantation; 4.Diagnosis of sepsis more than 24 hours before enrollment. 5.History of blood transfusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma YAP1 levels;AST;ALT; | — |
Countries
China
Contacts
Public ContactShao Jun
Northern Jiangsu People's Hospital
Outcome results
None listed