Perioperative Pulmonary Injury
Conditions
Interventions
Propofol group (group B):Anesthesia induction propofol 1.5-2.5 mg/kg, anesthesia maintenance propofol 4-6 mg · kg-1 · h-1
Cyclophenol group (H group):Anesthesia induced cyclosporine 0.4-0.6 mg/kg, anesthesia maintenance cyclosporine 0.8-1.2 mg · kg-1 · h-1
Sponsors
The Second Norman Bethune Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.ASA I-III 2.Aged 60-75 years 3.Surgery duration >=120 minutes 4.With informed consent from patients and their families
Exclusion criteria
Exclusion criteria: 1.Patients with severe systemic diseases and moderate to severe ventilatory dysfunction on preoperative pulmonary function tests. 2.Patients with intraoperative blood loss > 300 ml or those who received blood transfusions. 3.Patients who develop severe hypotension intraoperatively and show no improvement after the use of vasoactive drugs more than 3 times. 4.Patients who are transferred to the intensive care unit (ICU) postoperatively. 5.Patients who develop refractory hypoxemia intraoperatively. 6.Patients with intellectual or behavioral disorders who are unable to provide adequate informed consent. 7.Patients who are allergic to the drugs used in this study or have a history of alcohol or sedative-analgesic drug abuse. 8.Patients who voluntarily withdraw from this study before its completion or are concurrently enrolled in other studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary function;NETs generate biomarkers;LUS;Inflammatory factors; | — |
Countries
China
Contacts
Public ContactZhao Peng
The Second Norman Bethune Hospital of Jilin University
Outcome results
None listed