Ulcerative colitis
Conditions
Interventions
The first stage experimental group:Combined intervention of Bifidobacterium longum infantile subspecies CCFM1426 and vitamin A
The second stage experimental group:Combined intervention of Bifidobacterium longum infantile subspecies CCFM1426 and vitamin A
The second stage placebo group:Maltodextrin
Sponsors
Yixing People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. The subjects meets the diagnostic criteria for ulcerative colitis (UC); 2. Age: 18 years old to 75 years old, gender not limited; 3. Good compliance, capable of abiding by the regulations as required by clinical trials; 4. The subject or guardian has signed the informed consent form; 5. Long-term use of mesalazine preparations; 6. Patients fill out the written informed consent form and commit to cooperating with the study throughout the trial period.
Exclusion criteria
Exclusion criteria: 1. Those who have used non-steroidal drugs within the past month; 2. Those who have received hormone, calcium or vitamin D treatment within the past one month; 3. Long-term smokers, pregnant women, and those with abnormal liver or kidney functions; 4. Those who have taken or used antibiotics for treatment within 1 months; 5. Patients who have taken microecological preparations, dietary supplements or probiotics within the past month; 6. Patients who have undergone significant changes in their dietary habits recently; 7. Patients with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improve the Mayo Activity score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life Score - Inflammatory Bowel Disease Questionnaire;TNF-a;IL-1ß;IL-6;IL-8;IL -10;IgE;IgA;IgM;Calprotectin;metagenome;non-targeted metabolome;White blood cells;red blood cells;hemoglobin;platelet count;erythrocyte sedimentation rate;Endotoxin;D-lactic acid;diamine oxidase;lipopolysaccharide;C-reactive protein;prealbumin;retinol;retinoic acid;albumin;D-dimer;fibrinogen;vasoactive intestinal peptide;substance P;5-hydroxytryptamine;catalase;superoxide dismutase;glutathione peroxidase;malondialdehyde; | — |
Countries
China
Contacts
Public ContactPan Qi
Yixing People's Hospital
Outcome results
None listed