Obesity
Conditions
Interventions
experimental group:The subject wore a nasal clip, and the average concentration of 2-oxovaleric acid hydrogel released from the nasal clip was 1075ng/l. The duration was controlled within 1 hour. Afte
control group:There was only hydrogel in the nasal clip and no 2-oxovaleric acid liquid solvent. The other experimental conditions and intervention measures were consistent with those of the experimen
Sponsors
Central Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Population subjects: (1) People aged 18 to 65 years with normal olfactory function; (2) Physical and mental health, no family history of hereditary obesity; (3) The experimental compliance was good; (4) The patient or close relatives can fully understand the informed consent form, agree to participate in the study and sign the informed consent form
Exclusion criteria
Exclusion criteria: If any of the following criteria is met, the subject cannot be enrolled in this study: (1) those who participated in any drug clinical trial within 3 months before the trial; (2) Chronic or active gastrointestinal diseases such as esophageal disease, gastritis, gastric ulcer, enteritis, active gastrointestinal bleeding or gastrointestinal surgery within three years; (3) Those who have a history of cardiovascular system, endocrine system, urinary system, nervous system, respiratory system, hematology, Immunology (including personal or family history of hereditary immune deficiency), psychiatry, metabolic abnormalities and other diseases, and the investigator believes that there is still clinical significance at present; (4) Have a history of allergy to drugs, food or other substances; (5) Patients with a history of tumor, epilepsy, recurrent headache, and tuberculosis infection; (6) Those who cannot tolerate venous puncture or have a history of blood and needle syncope; (7) Had undergone surgery within 3 months before the trial; Or planned surgical procedures during the study period; (8) Vaccinees within 3 months before the trial; (9) Those who have used any drug within 30 days before the test; (10) Blood donors or massive blood loss (> 400 ml) within 3 months before the test; (11) Alcoholics or regular drinkers within 6 months before the test, i.e. drinking more than 14 units of alcohol per week (1 unit =360 ml of beer or 45 ml of 40% alcohol or 150 ml of wine); Or unwilling to stop drinking alcohol or use any alcohol containing products during the test; Or positive alcohol breath test result (> 0.0 mg/100 ml); (12) Drinking too much tea, coffee and / or caffeinated beverages (more than 8 cups, 1 cup =250 ml) every day, or disagreeing to stop drinking tea, coffee and / or caffeinated beverages during the test; (13) Those who have special requirements for diet, cannot follow the unified diet, or are lactose intolerant; (14) Drug abusers or those who used soft drugs (such as marijuana) within 3 months before the test or hard drugs (such as cocaine, phencycline, etc.) within 1 year before the test; (15) For those with creatinine clearance less than 80 ml/min {Cockcroft Gault formula for creatinine clearance calculation: crcl=[(140 age) × body weight (kg)] / [0.814 × SCR (µ mol/l)]; (16) Positive results of urine drug screen (morphine, methamphetamine, ketamine, dimethyldioxoamphetamine, tetrahydrocannabinol acid, cocaine); (17) Physical examination, electrocardiogram, laboratory examination, color Doppler ultrasound, chest anteroposterior film, vital signs and test related examination abnormalities with clinical significance (subject to the judgment of clinicians); (18) Those with positive results of infectious disease screening; (19) Smoking test (nicotine urine test) results positive; (20) There are metal objects in the body (such as cardiac pacemaker and artificial joint); (21) claustrophobia: unable to tolerate confined space; (22) severe cardiopulmonary diseases such as acute exacerbation of chronic obstructive pulmonary disease (COPD) and uncontrolled heart failure; (23) recent intense exercise or extreme diet: high-intensity exercise within 24 hours or fasting >12 hours (standardized pretreatment is required); (24) the subject may not be able to complete the study due to other reasons, or the investigator determines that there are other reasons for not participating in the test; (25) people with anosmia whose baseline TDI score is l
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Appetite VAS score;Food calorie intake;Human metabolic compartment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Infrared thermal imaging;Head MRI; | — |
Countries
China
Contacts
Public ContactYongfeng Song
Central Hospital Affiliated to Shandong First Medical University
Outcome results
None listed