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Multimodal Assessment of Clinical Efficacy: Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation in Chronic Disorders of Consciousness

Multimodal Evaluation of Transcranial Direct Current Stimulation and Repetitive Transcranial Magnetic Stimulation in Chronic Disorders of Consciousness: A Neurobehavioral-Electrophysiological Randomized Controlled Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105528
Enrollment
Unknown
Registered
2025-07-04
Start date
2025-07-15
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prolonged Disorders of Consciousness

Interventions

tDCS/rTMS/tDCS+rTMS:The tDCS group received tDCS stimulation.
rTMS:rTMS group received rTMS stimulation.
tDCS+rTMS:TDCS+rTMS group receiving tDCS+rTMS stimulation

Sponsors

Shandong Provincial Third Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age >= 18 years old; 2.Craniocerebral injury is the main pathogenic factor confirmed by cranial CT and/or MRI examination, accompanied by consciousness disorders, and the pathogenic factors are traumatic, ischemic, and hypoxic; 3.The duration of consciousness disorders is >= 28 days; 4.The level of consciousness impairment was assessed as VS or MCS using the CRS-R scale; 5.Stable vital signs; 6.The patient's family voluntarily informed and signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1.Patients with critical illness and unstable vital signs 2.Active cerebral hemorrhage; 3.Patients with intracranial retention of metal objects; 4.Individuals with pacemakers in their bodies; 5.Consciousness disorders caused by other reasons; 6.Previous history of epilepsy or family history of epilepsy; 7.Patients with severe heart, liver, kidney and other important organ failure; 8.Pregnancy.

Design outcomes

Primary

MeasureTime frame
CRS-R;MMN;

Countries

China

Contacts

Public ContactWang Xin

Shandong Provincial Third Hospital

iamwangxin@163.com+86 151 6531 0362

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026