Colorectal cancer
Conditions
Interventions
Gold Standard:Pathological diagnosis
Index test:16S rRNA sequencing?Metabolomics
Sponsors
The Seventh Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients with microsatellite-stable (MSS) colorectal cancer (CRC); 1) Pathologically confirmed diagnosis of MSS type CRC; 2) Be between the ages of 18-75 years; 3) Not receiving any anti-tumor therapy (including surgery, chemotherapy, radiotherapy, immunotherapy, etc.). 2.Healthy volunteers; 1) Age, gender matched to patient group; 2) no history or family history of CRC; 3) No history of other major diseases that may significantly affect gut health (e.g., inflammatory bowel disease) 3.Willing to participate in the study and sign the informed consent form; 4.Able to actively cooperate with sample collection and questionnaire completion;
Exclusion criteria
Exclusion criteria: 1.Individuals who have used antibiotics, probiotics, or other medications that may significantly affect the gut microbiota within the past month; 2.Individuals with a history of severe hepatic or renal dysfunction, immune system disorders, or psychiatric diseases; 3.Individuals with a history of malignant tumors other than CRC; 4.Participants who do not meet sample collection criteria (e.g., unable to provide stool or serum samples, or whose samples may be of poor quality);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in the relative abundance of Bacteroides species;Accuracy;Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactQingyuan Zhang
The Seventh Affiliated Hospital Sun Yat-sen University
Outcome results
None listed