Heart Rate Variability (HRV)
Conditions
Interventions
Group R1 (Trial 1):Remimazolam 0.15 mg
Group R2 (Trial 1):Remimazolam 0.25 mg
Remimazolam tosylate group (trial 2):The effective induction dose of remimazolam tosilate combined with remifentanil determined in Experiment I
Propofol group (trial 2):The effective induction dose of propofol combined with remifentanil.
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective surgery, age 60~80 years old, body mass index (BMI) 19.0-26.0 kg/m^2, ASA I-III. grade; 2. No history of long-term smoking and alcoholism, no abnormalities in heart, lung, liver and kidney function, no spinal cord injury, endocrine diseases, no hyperthyroidism or hypothyroidism, no acid-base imbalance and electrolyte disorders; 3. Have not used drugs and glucocorticoids that affect autonomic nerve function within two weeks before surgery; 4. Normal cognitive and mental state.
Exclusion criteria
Exclusion criteria: 1. Conventional electrocardiogram (ECG) shows interference with ECG analysis, such as left and right bundle branch block, left ventricular hypertrophy, atrial fibrillation or flutter, second- or third-degree atrioventricular block, QT interval prolongation; 2. Patients with diseases of the central nervous system and autonomic nervous system; Those who use ß receptor blockers or drugs affecting the central nervous system before surgery; 3. Those who are allergic to benzodiazepines and any of the ingredients of this product or have a history of severe allergies in the past, combined with head injury, intracranial hypertension or a history of cerebrovascular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart Rate Variability (HRV); | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate;Blood pressure;Blood oxygen saturation; | — |
Countries
China
Contacts
Public ContactZhong Yi
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed