Carotid plaque
Conditions
Interventions
Norepinephrine group:One minute prior to carotid artery occlusion, norepinephrine (NE) was administered via intravenous infusion at a dose of 0.01–0.1 µg/(kg·min), with a constant infusion rate of 0.1
Phenylephrine group:One minute prior to carotid artery occlusion, phenylephrine (PE) is administered via intravenous infusion at a dose of 0.1–0.6 µg/(kg·min), with a constant infusion rate of 0.1–10
Sponsors
Affiliated Hospital of Inner Mongolia Medical University
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Inclusion criteria
Inclusion criteria: (1)Unilateral carotid endarterectomy is planned for an alternative time, provided that the degree of carotid artery stenosis on the affected side exceeds 70%. (2) Presence of irregular shunting. (3) Age of 50 years or older. (4) Signed informed consent form. (5) Clear transcranial Doppler signals obtainable via the acoustic window. (6) ASA Physical Status Classification System Grade II - III. (7) Absence of psychiatric disorders or severe audio-visual impairments. (8) Ability to independently complete preoperative cognitive function testing with a preoperative MMSE (Mini-Mental State Examination) score of >=23.
Exclusion criteria
Exclusion criteria: (1) Patients with allergies or contraindications to relevant anesthetic medications during surgery. (2) Patients taking medications or with a history of alcohol dependence. (3) Patients diagnosed with chronic pain syndrome or Alzheimer's disease. (4) Patients refusing participation or withdrawing consent midway through the study. (5) Patients with an educational level below junior high school and a preoperative Mini-Mental State Examination (MMSE) score of less than 23. (6) Patients requiring intraoperative transfer to another location. (7) Patients experiencing a sustained intraoperative blood pressure decrease exceeding 20% of baseline for more than 10 minutes, or intraoperative blood loss exceeding 20% of total blood volume. (8) Patients requiring postoperative admission to the ICU with endotracheal intubation, exhibiting significant delayed recovery, or unable to complete extubation in the operating room.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cognitive function;C-reactive protein ; | — |
Secondary
| Measure | Time frame |
|---|---|
| The average peak blood flow velocity of the middle cerebral artery ;Oxygen saturation of the affected side of the brain;Glial fibrillary acidic protein ; | — |
Countries
China
Contacts
Public ContactLibiao Li
Affiliated Hospital of Inner Mongolia Medical University
Outcome results
None listed