Myocardial infarction
Conditions
Interventions
Experimental group:Moderate-Intensity Continuous Training followed by high-Intensity Interval Training
Control group:High-Intensity Interval Training followed by Moderate-Intensity Continuous Training
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 18 to 75 years old, gender not restricted; 2. A clear history of myocardial infarction and having undergone revascularization (PCI or CABG), with at least 3 months post-operation; 3. Sedentary was defined as those who exercised for less than 3 hours per week and spent 8 hours or more in static activities per day. Those who do not meet the above conditions are defined as non-sedentary people. The static activity time refers to the total time of subjects using a computer, writing materials at work, having meetings, watching TV, playing computer games, playing chess, and reading after work every day. Weekly exercise time refers to the total number of hours per week that subjects participate in moderate intensity (slightly strenuous) or above fitness exercises. 4. The patients with low to moderate risk were classified as such (the specific risk stratification method can be found in the Exercise Risk Stratification Table for Patients with Coronary Heart Disease); 5. The participants had good compliance, voluntarily participated in the study, agreed to take part in the research, and were able to sign the written informed consent form.
Exclusion criteria
Exclusion criteria: 1. The patient is in the unstable stage of myocardial infarction (within 2 weeks of myocardial infarction); 2. Those with elevated myocardial injury markers (including creatine kinase isoenzyme or troponin); 3. Decompensated or acute heart failure, with left ventricular ejection fraction < 40%; 4. Occurrence of angina pectoris during low-intensity exercise (< 5.0 metabolic equivalent), or resting angina pectoris; 5. Presence of severe arrhythmias at rest, during exercise, or after exercise termination (frequent premature ventricular contractions, ventricular tachycardia, ventricular flutter and fibrillation, supraventricular tachycardia, rapid atrial fibrillation, severe bradycardia, II°II or above atrioventricular conduction block); 6. Those who have had pacemaker, ICD, or CRT implantation previously; 7. Those with severe mental and psychological disorders; 8. Those with other serious diseases (severe pneumonia, cerebral hemorrhage or subarachnoid hemorrhage, cerebral infarction, severe liver and kidney failure, severe anemia, etc.); 9. Those with severe diseases that limit exercise testing and training (such as post-stroke sequelae, lumbar spinal stenosis, severe degenerative knee arthritis); 10. Those with diseases that result in an expected lifespan of less than 1 year (such as malignant tumors); 11. Those who have participated in systematic exercise training; 12. Those who have engaged in dieting and weight loss behaviors in the past 2 weeks; 13. Those who are currently participating in other clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-induced differentially expressed proteins in adult plasma;High-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)-induced differentially expressed metabolites in adult plasma; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate response to MICT and HIIT;Systolic and diastolic blood pressure response to MICT and HIIT;Rating of perceived exertion during MICT and HIIT;Parameters of ventilatory and gas exchange dynamics during MICT and HIIT; | — |
Countries
China
Contacts
Public ContactLiu Suixin
Xiangya Hospital Central South University
Outcome results
None listed