Alzheimers disease
Conditions
Interventions
Undergoing LVA surgery group:Bilateral deep cervical lymph-venous anastomosis
Not undergoing LVA surgery group:None
Sponsors
General Hospital of the Central Theater of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
55 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion Criteria: (1) Age 55~80 years old; (2) The subject has received primary school education or above and is able to complete the prescribed cognitive ability tests and other tests; (3) memory impairment for at least 12 months, with a gradual deterioration trend; (4) Diagnosed with AD according to the 2024 National Institute on Aging-Alzheimer's Society diagnostic criteria for AD; (5) Mild to severe disease, with a score of <= 20 on the Concise Mental State Examination (MMSE); (6) Hamilton Depression Rating Scale total score <= 10 points; (7) head MRI and oblique coronal hippocampal scan, which showed the highest probability of AD; (8) Subjects had stable and reliable caregivers, or at least frequent contact with caregivers (at least 4 days a week, at least 2 hours a day).
Exclusion criteria
Exclusion criteria: Exclusion Criteria: (1) Dementia caused by other causes, including vascular dementia, central nervous system infection, Creutzfeldt-Jakob disease, Huntington's disease, Parkinson's disease, Lewy body dementia, traumatic dementia, other physical and chemical factors (such as drug poisoning, alcoholism, carbon monoxide poisoning, etc.), major physical diseases (such as hepatic encephalopathy), intracranial mass lesions (such as brain tumors), endocrine disorders or other factors; (2) History of neurological diseases (including stroke, neuromyelitis optica, Parkinson's disease, epilepsy); (3) Unstable or severe cardiac, pulmonary, hepatic, renal or hematopoietic diseases; (4) visual or auditory impairment that interferes with the completion of neuropsychological tests and scale assessments; (5) alcohol or drug abuse; (6) suffer from mental illness, including major depression; (7) The subject was unable to cooperate with the operation and postoperative management.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood oxygen signal;Mini-Mental State Examination score;Alzheimer’s disease assessment scale-cognitive subscale score;Alzheimer’s disease cooperative study scale for activities of daily living score; | — |
Secondary
| Measure | Time frame |
|---|---|
| neuropsychiatric inventory score; | — |
Countries
China
Contacts
Public ContactSong Jian
General Hospital of the Central Theater of the Chinese People's Liberation Army
Outcome results
None listed