osteoarthritis of the knee
Conditions
Interventions
Intervention group:iTBS stimulation + conventional physiotherapy
Phase 1: Test group:All stimulation that the participant will receive, including left dorsolateral prefrontal iTBS true stimulation, right dorsolateral prefrontal iTBS true stimulation, pseudostimulat
Sponsors
Guangzhou sport university
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Healthy subjects: 1. Between 18 and 65 years of age Patients with osteoarthritis of the knee: 1. Aged between 18 and 75 years old and able to give consent. 2. Meet the diagnostic criteria for osteoarthritis of the knee according to the Chinese Osteoarthritis Guidelines and report having unilateral or bilateral knee OA pain; 3. Chronic knee pain (lasting at least 3 months) with a visual analogue scale (VAS) score of =5/10.
Exclusion criteria
Exclusion criteria: Healthy subjects: 1. Contraindications to TMS (including, but not limited to, metal inside the head, excluding dental work, professional drivers, pregnant or breastfeeding, history of seizures);. 2. History of neurologic or psychiatric disorders or use of psychotropic medications; and 3. History of cardiac abnormalities or current cardiac abnormalities or taking medications related to cardiac disease. Patients with osteoarthritis of the knee: 1. Contraindication to TMS. 2. Significant medical or neurological illness unrelated to the pain condition 3. Planned total knee replacement surgery or other major treatment change within 1 month of initial evaluation. 4. Intra-articular injection therapy within the past 4 weeks. 5. Taking centrally active medications other than stable antidepressants or opioid analgesics. 6. Taking medication, alcohol or recreational drugs that are thought to increase the risk of seizures and/or syncope
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| heart rate variability index;Visual Analogue Scale;Western Ontario and McMaster Universities Arthritis Index;seed-based function connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Short Form 36 Health Survey;Pain Catastrophizing Scale;oxyhemoglobin concentration; | — |
Countries
China
Contacts
Public ContactHou Xiaohui
Guangzhou sport university
Outcome results
None listed