Skip to content

Multimodal Imaging Study on the Correlation between Central Nervous System Mechanisms and Retinal Structure-Function in Anisometropia with and without Amblyopia

Multimodal Imaging Study on the Correlation between Central Nervous System Mechanisms and Retinal Structure-Function in Anisometropia with and without Amblyopia

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500105466
Enrollment
Unknown
Registered
2025-07-03
Start date
2025-07-05
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anisometropia and Anisometropic Amblyopia

Interventions

Observation group:After the participants were included, they were divided into groups according to the examination conditions: normal control group
anisometropia without amblyopia group
Ansometropia with amblyopia group

Sponsors

Changsha Aier Eye Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
6 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1. Age 6-18 years old, diagnosed with anisometropia (equivalent spherical power binocular difference (IOD)>=1.00D; or any meridian astigmatism difference >=1.50D); 2. Have undergone refractive correction > = 3 months; 3. Occlusion treatment history group: Occlusion group: received masking treatment >=6 months; Non-masking group: never received masking treatment; 4. No history of eye diseases such as strabismus and abnormal color vision except for refractive error; 5. No history of ocular trauma or surgery; 6. No history of systemic diseases such as epilepsy; 7. Able to cooperate with the completion of various examinations

Exclusion criteria

Exclusion criteria: 1. Presence of manifest strabismus. 2. Presence of nystagmus. 3. Presence of organic eye diseases (e.g., glaucoma, retinopathy, optic neuropathy, cataract). 4.History of ocular surgery, organic eye diseases, diabetes, or other systemic diseases known to affect visual function. 5. Presence of neurological or vestibular-related balance disorders. 6. Refusal to provide written informed consent or inability to cooperate with and complete the full examination protocol.

Design outcomes

Primary

MeasureTime frame
Degree of Anisometropia;OCT/OCTA;mfERG;

Countries

China

Contacts

Public Contactzhikuan yang

Changsha Aier Eye Hospital

yangzhikuan@aierchina.com+86 133 8007 1988

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026