Bullous diseases of the oral mucosa
Conditions
Interventions
Healthy control:None
Mucosal-dominant pemphigus vulgaris:None
Low-risk mucous membrane pemphigoid:None
Sponsors
West China Hospital of Stomatology, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1: Case group: low-risk mucosal pemphigus (1) Clinical manifestations: blisters, erosion or diffuse erythema on the gums, and/or oral mucosal blisters or erosion, without skin, eye, pharynx, throat, esophagus, anus, and external genital mucosal lesions. (2) Direct immunofluorescence shows linear deposition of IgG and/or C3 in the epithelial basement membrane, accompanied by deposition of IgA and IgM. (3) Histopathology shows the formation of subepithelial blisters, with separation of the epithelial layer from the lamina propria. (4) ELISA detected the presence of anti BP180 antibodies in the serum. Those who meet at least (1)+(2) or (1)+(2)+(4) criteria can be diagnosed as low-risk mucosal pemphigus. 2: Case group: Mucosal dominant pemphigus vulgaris (1) Clinical manifestations: ? Oral mucosal blisters or erosion, without skin and other mucosal lesions in the body cavity? Ni's sign (+); ? After the blister ruptures, it forms stubborn erosion (2) Histopathology: Epidermal/intraepithelial blister formation (spinous layer lysis) (3) Immunodiagnostic indicators: ? Direct immunofluorescence shows a network deposition of IgG (or accompanied by C3) between spinous cells; ? ELISA detection shows positive results for anti Dsg3 antibodies (or accompanying anti Dsg1 antibodies). Diagnosis can be made by meeting at least one of the "clinical manifestations", at least one of the "tissue pathology", and "immune diagnostic indicators" At least 2 of the "clinical manifestations" and 2 of the "immune diagnostic indicators" can also be diagnosed as mucosal dominant pemphigus vulgaris. 3: Control group: Healthy adults without oral mucosal disease, periodontal disease, and caries
Exclusion criteria
Exclusion criteria: 1: Case group (low-risk mucous membrane pemphigoid and mucosa-dominant pemphigus vulgaris): (1) Pemphigus vulgaris and mucous membrane pemphigoid lesions involving oral mucosa and other body cavity mucosa and skin lesions at the same time; (2) Suffering from other oral mucosal diseases; (3) Those who have used local or systemic immunological preparations within 3 months, and those who have used antibiotics and/or hormones locally or systemically within 1 month. 2: Control group: (1) Individuals suffering from severe other systemic diseases (2) Individuals who have received local or systemic use of immune preparations within 3 months, and those who have received local or systemic use of antibiotics and/or glucocorticoids within 1 month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral microbial composition; | — |
Countries
China
Contacts
Public ContactXin Zeng
West China Hospital of Stomatology, Sichuan University
Outcome results
None listed