Painless gastrointestinal endoscopy
Conditions
Interventions
Esketamine Group:The starting dose of esketamine is 0.2 mg/kg, and then decreases or increases by 0.02 mg/kg according to positive or negative.
Sponsors
Xiangyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Gender irrestricted, age 18 - 65; 2. BMI 18 - 24 kg /m^2 ; 3. ASA Level I- III; 4. Planned implementation of painless gastrointestinal endoscopy; 5. Have the ability to act independently, have a clear consciousness, and understand the content of the investigation.
Exclusion criteria
Exclusion criteria: 1. ASA > Class III.; 2. History of allergy to benzodiazepines or contraindications; 3. Abnormal renal function (urea nitrogen = 1.5× ULN, serum creatinine greater than the upper limit of normal); 4. abnormal liver function; 5. History of cardiac disease (cardiac function > grade III.); 6. Those who are unable to cooperate: hearing impairment, mental illness, etc.; 7. History of long-term use of analgesic and sedative drugs or drug abuse; 8. Participated in drug clinical trials as a subject in the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart rate;Mean arterial pressure;Oxygen saturation;Respiratory rate;ED50; | — |
Countries
China
Contacts
Public ContactTian Shiming
Xiangyang Central Hospital
Outcome results
None listed