Postoperative delirium
Conditions
Interventions
Experimental group:The control group received conventional anesthesia regimen, and postoperative intravenous opioid anesthesia (sufentanil) analgesia pump was used. The experimental group adopted a lo
Continuous intravenous infusion of ketamine during surgery
After surgery, a multimodal analgesia regimen mainly consisting of local infiltration anesthesia with bupivacaine liposomes, nerve block, and nonsteroidal anti-inflammatory drugs was adopted.
Control group:Routine anesthesia methods during surgery and postoperative intravenous analgesia pump analgesia.
Sponsors
Nanjing Drum Tower Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65; 2. According to the "Common Diagnostic Classification and Functional Outcome Evaluation Criteria of Orthopedics", the patient had a clear history of trauma and was diagnosed as hip fracture by preoperative X-ray film; 3. Elected hip fracture surgery at Nanjing Gulou Hospital, ASA I-III; 4. The patient has a primary school education level or equivalent education level or above, and was able to communicate normally before the injury; 5.Preoperative undiagnosed mental disorders, cognitive impairments, and important organ dysfunction.
Exclusion criteria
Exclusion criteria: 1. Individuals with allergies to related drugs and contraindications to the use of ketamine; 2. Patients who have fractures in other parts before surgery and undergo other types of surgeries during hospitalization; 3. Individuals with a history of delirium and Alzheimer's disease; 4. Long term use of painkillers, history of mental illness, and failure to take relevant medications on time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative POD in patients.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The dosage of sufentanil and remifentanil during surgery;;The occurrence of postoperative complications such as pain, nausea, and vomiting;;Changes in inflammatory and POD specific indicators during the perioperative period of patients;;The impact of postoperative extubation time, postoperative hip joint functional status, and postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactCui Shihe
Nanjing Drum Tower Hospital
Outcome results
None listed