Postoperative pain
Conditions
Interventions
Intrathecal morphine+ropivacaine 6mg group:N/A
Intrathecal morphine group (Group A):N/A
Intrathecal morphine+ropivacaine 4mg group:N/A
Control group (conventional intravenous analgesia group):N/A
Intrathecal morphine+ropivacaine 8mg group:N/A
Sponsors
The Fourth Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Electively perform major chest and abdominal surgery under anesthesia and sign an informed consent form; 2.Age 18-75 years old, American anesthesiologist classification I-II; 3.Those who have not taken analgesics, sedatives or are allergic to them within 72 hours before surgery; 4.The anesthesia time is 2-5 hours; 5.Willing to cooperate with research and postoperative follow-up;
Exclusion criteria
Exclusion criteria: 1.Unable to communicate and cooperate before surgery, resulting in coma, severe dementia, severe mental disorders, etc; 2.Patients with obvious liver, liver and kidney dysfunction and intolerance to surgery; 3.Patients with poor compliance, coagulation dysfunction, spinal deformities, infection at the puncture site, and difficulty cooperating with the puncture operation to complete treatment; 4.Unexpected drug allergy during surgery, switch to open surgery; 5.Unable to follow up within three days after surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Observation of intraoperative remifentanil dosage and postoperative 72 hour VAS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurrence of toxic and anesthetic drug-related adverse reactions (postoperative dizziness, respiratory depression, nausea and vomiting, urine retention, catheter-related bladder discomfort (CRBD), pruritus, hypotension, etc.); | — |
Countries
China
Contacts
Public ContactXuesong Ma
The Fourth Affiliated Hospital of Harbin Medical University
Outcome results
None listed