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Effects of prophylactic infusion of constant-rate norepinephrine or phenylephrine on neonatal outcomes during caesarean section: a randomized, double-blind trial

Effects of prophylactic infusion of norepinephrine or phenylephrine on neonatal outcomes during caesarean section

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105396
Enrollment
Unknown
Registered
2025-07-02
Start date
2025-07-02
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Internal environment of the fetus

Interventions

Sponsors

The Second People's Hospital of Hefei
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Pregnant women aged between 18 and 40 years old; 2.ASA classification I-II; 3. Single term pregnancy; 4. Undergo spinal anesthesia to perform cesarean section, and collection of umbilical cord blood during the perioperative period; 5.Agree to participate in the study

Exclusion criteria

Exclusion criteria: 1. Unable or refusing to sign the informed consent form; 2. Those who are allergic to norepinephrine or phenylephrine or are not suitable for use; 3. Those with known abnormal fetal development; 4. Those who are accompanied by severe heart, brain, liver, and kidney diseases; 5. Those who are currently using monoamine oxidase inhibitors or tricyclic antidepressants; 6. Those who have contraindications to spinal anesthesia; 7. Those who are unable to communicate and cooperate.

Design outcomes

Primary

MeasureTime frame
Base excess;

Secondary

MeasureTime frame
Potential hydrogen (pH);Partial pressure of oxygen (PO2);Partial pressure of carbon dioxide (PCO2);Bicarbonate (HCO3-);Blood glucose;Incidence of fetal acidosis;

Countries

China

Contacts

Public ContactJinfeng Bao

The Second People's Hospital of Hefei

252295142@qq.com+86 156 5518 0780

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026