Depressive disorder
Conditions
Interventions
Active treatment group:Active rTMS combined with DBT-A
Sham treatment group:Sham rTMS combined with DBT-A
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Age
13 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Age>=13 years and 13; 4. Meet the DSM-5 diagnostic criteria for depressive disorders; 5. The number of self-injuries is greater than 5 times within 12 months, and there are thoughts of self-harm in the past month; 6. Agree to participate in the study, and the adolescent and parents sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Consistent with DSM-5 pervasive developmental disorder, psychotic disorder, bipolar disorder, borderline personality disorder, attention deficit hyperactivity disorder, and history of severe cerebral organic disease, epilepsy or other major neurological disorders; 2. History of mild to severe drug use disorder within the last 3 months; 3. Have a history of failed brain stimulation (rTMS, electroconvulsive therapy, or transcranial electrical stimulation) in the past or are undergoing electroconvulsive therapy; 4. The head has any type of non-removable metal or other metal device or object implanted in or near the head; cardiac pacemakers, etc.; 5. The use of benzodiazepines, bupropion, valproate drugs that significantly affect the stimulation threshold; 6. Use of antidepressants or high doses of antipsychotic drugs in excess of the dose, such as sertraline > 200 mg/day, escitalopram > 20 mg/day, fluoxetine > 60 mg/day, fluvoxamine > 300 mg/day, risperidone > 2 mg/day, olanzapine > 10 mg/day, quetiapine greater than 400 mg/day, aripiprazole > 20 mg/day.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Beck Depression Self-Rating Scale score;Ottawa Self-Injury Questionnaire Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Childhood depressive disorder self-rating scale score;Anxiety Mood Disorder Screening Form score in children;Simplified Coping Style Questionnaire;N-back task;Emotional stroop task;Stop-signal task;Hamilton Depression Rating Scale score; | — |
Countries
China
Contacts
Public ContactWenhong Cheng
Shanghai Mental Health Center
Outcome results
None listed