Helicobacter pylori infection
Conditions
Interventions
Test group A:20 mg Vonoprazan twice ,1g Amoxicillin three times and 0.25g Saccharomyces boulardii twice daily for 10 days.
Test group B: 20 mg Vonoprazan twice ,1g Amoxicillin three times and 0.25g Saccharomyces boulardii twice daily for 14 days.
Test group C:20 mg Vonoprazan twice ,1g Amoxicillin three times daily for 10 days.
Control group: 20mg Vonoprazan twice ,1g Amoxicillin three times daily for 14 days.
Sponsors
Department of gastroenterology in people's hospital of Leshan
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 50 to 80 years,maleor female. 2. Did not take antibiotics, bismuth, or Chinese traditional medicines with antibacterial effects in the previous month, and did not take PPI, H2 receptor antagonists, or other drugs that affect H. pylori activity within the previous 2 weeks. 3. Diagnosis of H. pylori infection by carbon-13/14 urea breath test (13C/14C-UBT) or immunohistochemical staining of biopsy samples,treatment-naive. 4. Provided informed consent to participate in this study.Patients with complete medical records and follow-up records.
Exclusion criteria
Exclusion criteria: 1. Presence of severe diseases or clinical conditions, such as liver disease, lung disease, and cardio vascular disease and low immunity. 2. Allergy to penicillin or other medications used in this clinical trial. 3. Patients with communication disorders due to mental illness. 4. pregnancy or lactation. 5. Presence of severe gastrointestinal diseases, such as malignant tumor, gastrointestinal bleeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eradication rate of H.pylori infection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reactions; | — |
Countries
China
Contacts
Public ContactDeng Xuejie
People's hospital of Leshan
Outcome results
None listed