Knee Osteoarthritis
Conditions
Interventions
Control group:Conventional treatment + conventional tranexamic acid (intravenous infusion at 10mg/kg 15 minutes before surgery and during the operation for 30 minutes)
Test Group A:Conventional treatment + systemic continuous administration of tranexamic acid (intravenous infusion at 10mg/kg 15 minutes before surgery, 30 minutes during surgery, 2 hours after surgery
Test Group B:Conventional treatment + Fresh Frozen Plasma (200ml of fresh frozen plasma was administered 30 minutes before the operation)
Sponsors
The Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age range: 50–80 years old, gender not restricted; 2. Diagnosed with end-stage osteoarthritis, Kellgren-Lawrence grade (KL) 3–4, standard conservative treatment ineffective for >6 months; 3. Resided in high-altitude areas for >3 months; 4. Within three months of the perioperative period, no joint cavity puncture or drug injection, no joint surrounding dressing, etc., were performed, and the infection risk assessment was low; 5. The participants/their guardians can understand the research purpose, have sufficient compliance, and are willing to participate in this study and sign the informed consent form (ICF).
Exclusion criteria
Exclusion criteria: 1. Those allergic to tranexamic acid; 2. Those with liver or kidney dysfunction as detected before the operation; 3. Those who received anticoagulant treatment due to concurrent cardiovascular or cerebrovascular diseases before the operation; 4. Those diagnosed as having suppurative infection of the knee joint through tissue culture or case diagnosis during or after the operation; 5. Those with a clear diagnosis of rheumatoid arthritis, gouty arthritis, or traumatic arthritis; 6. Those with a history of thrombosis; 7. Those who refused to participate in or withdrew from this study by themselves or their family members.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average total blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood routine examination;C-reactive protein;Erythrocyte sedimentation rate;Anteroposterior and lateral radiographs of the knee joint;Full-length X-ray of both lower limbs; | — |
Countries
China
Contacts
Public ContactZhang Yuan
The Second Affiliated Hospital of Army Medical University
Outcome results
None listed