Carotid artery stenosis
Conditions
Interventions
SK Pretreatment Group I(0.25mg/kg):SK Preprocessing 0.25mg/kg
SK Pretreatment Group II(0.5mg/kg):SK Preprocessing 0.5mg/kg
SK Pretreatment Group III(0.75mg/kg):SK Preprocessing 0.75mg/kg
Placebo group(Cgroup):Give normal saline in equal volume
Sponsors
Central Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.age 60-80years old,No gende r limit; 2.Supernatural Sound/CTA/MRAConfirmed unilateral carotid stenosis>=70%Symptomsor=80%Asymptomatic; 3.Preoperative simple mental status check scale(MMSE)score>=24point; 4.ASA ?~?; 5.BMI18 ~30kg/m^2; 6.Voluntarily sign informed consent
Exclusion criteria
Exclusion criteria: 1.Previously, there were mental diseases (such as schizophrenia, depression, etc.), central nervous system history (history of epilepsy, Parkinson's syndrome, Alzheimer's disease, etc.); 2.Esketamine allergies or contraindications; 3.Use antidepressants, benzodiazepines or NMDA receptor modulators within 1 month before the operation; 4.Severe liver and kidney insufficiency; 5.The researchers determined that other situations were not suitable for participating in this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Simple Intelligent Mental Status Check Scale MMSE score; | — |
Secondary
| Measure | Time frame |
|---|---|
| One day before the operation/1 day after surgery/3 day after surgery/7day after surgery Perform the patient MoCA Cognitive function scores for scales;The incidence of agitation in patients with resuscitation chambers; wake up time, extubation time; adverse reaction rates, including: diplopia, hypertension, tachycardia, postoperative nausea and vomiting, dizziness and headache, etc.; | — |
Countries
China
Contacts
Public ContactFanjun Meng
Central Hospital Affiliated to Shandong First Medical University
Outcome results
None listed