Asthma
Conditions
Interventions
Sponsors
The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>=18 years old, both male and female. 2. Clear diagnosis of asthma: The diagnosis is based on the "GINA 2023" and China's "Guidelines for the Prevention and Treatment of Bronchial Asthma (2020 Edition)": 1. Clinical symptoms and signs of typical asthma: (1) Recurrent episodes of wheezing and shortness of breath, with or without chest tightness or cough, frequent at night and in the morning, often related to exposure to allergens, cold air, physical and chemical stimuli, upper respiratory tract infection, exercise, etc.; (2) Chronic persistent asthma at the time of attack and partially uncontrolled, scattered or diffuse wheezing can be heard in both lungs, and the expiratory phase is prolonged; (3) The above symptoms and signs can be relieved by treatment or spontaneously. 2. Objective examination of variable airflow limitation: (1) positive bronchodilator test (after inhalation of bronchodilator, FEV1 increased by >12%, and the absolute value of FEV1 increased by >200 ml); or an increase of >12% in FEV1 compared with baseline after 4 weeks of anti-inflammatory therapy, and an increase of >200 ml in absolute FEV1 (excluding respiratory tract infections). (2) Positive bronchial provocation test: the inhalation stimulant is generally methacholine or histamine, usually FEV1 decreases by =20% after inhalation stimulant, and the result is judged to be positive, indicating the presence of airway hyperresponsiveness. (3) The average daily diurnal variability rate of peak expiratory flow (PEF) (the sum of daily PEF diurnal variability rates for at least 7 consecutive days/total number of days 7) >10%, or the weekly PEF variability rate {(highest PEF value in 2 weeks - lowest PEF value)/[(highest PEF value in 2 weeks, lowest PEF)×1/2]×100%}>20%. Asthma is diagnosed if the above symptoms and signs are present, and one of the objective tests for airflow limitation is present, and wheezing, shortness of breath, chest tightness, and cough due to other disorders are excluded. 3. The patient has good compliance and has signed the informed consent form. 4. At least 1 acute exacerbation in the past 1 year
Exclusion criteria
Exclusion criteria: 1. Life-threatening asthma, asthma attacks requiring intubation; 2. Accompanied by severe primary lung diseases: pulmonary embolism, pulmonary hypertension, interstitial lung disease, emphysema, bronchiectasis and lung cancer, etc.; 3. History of severe cardiac, blood, digestive, kidney, liver, psychiatric, tumor, immune system diseases; 4. Diabetic subjects with hypokalemia and poor glycemic control; 5. Subject has a history of drug abuse, drug abuse, and alcohol abuse in the past 2 years; 6. Diagnosed with occupational asthma; 7. Pregnant women; 8. Predict patients with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute attack rate;Fractional exhaled nitricoxide; | — |
Secondary
| Measure | Time frame |
|---|---|
| spirometry;Total IgE; | — |
Countries
China
Contacts
Public ContactXin Yao
The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital)
Outcome results
None listed