The pain after laparoscopic radical resection for colorectal cancer
Conditions
Interventions
The group of sufentanil 2µg/kg:The formula for the postoperative intravenous patient-controlled analgesia pump is sufentanil 2 µg/kg + flurbiprofen axetil 200 mg, with a total volume of 150 ml.
The group of oliceridine 0.4mg/kg:The formula for the postoperative intravenous patient-controlled analgesia pump is oliceridine 0.4mg/kg + flurbiprofen axetil 200 mg, with a total volume of 150 ml.
The group of oliceridine 0.6mg/kg:The formula for the postoperative intravenous patient-controlled analgesia pump is oliceridine 0.6mg/kg + flurbiprofen axetil 200 mg, with a total volume of 150 ml.
The group of oliceridine 0.8mg/kg:The formula for the postoperative intravenous patient-controlled analgesia pump is oliceridine 0.8mg/kg + flurbiprofen axetil 200 mg, with a total volume of 150 ml.
Sponsors
Gansu Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Patients undergoing elective laparoscopic radical surgery for colorectal cancer; 2.Aged 18-75 years; 3.ASA classification I, II, or III; 4.BMI <= 30 kg/m^2; 5.Patients or their family members have been fully informed about the study and have signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Allergies to drugs used during anesthesia and postoperative analgesia; 2.History of chronic pain or long-term use of opioids; 3.Long-term use of antidepressants or sedatives; 4.Intraoperative conversion to open surgery; 5.Emergency surgery performed due to acute intestinal obstruction, intestinal bleeding, intestinal perforation, etc.; 6.Presence of severe respiratory diseases (e.g., severe COPD, bronchial asthma), severe cardiovascular diseases (e.g., ejection fraction 442 µmol/L); 7.Presence of active peptic ulcers; 8.Severe mental or neurological disorders affecting the patient's ability to understand and follow the study protocol (MMSE score < 26).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative NRS pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| The time of the first press of the PCIA pump after surgery.;Total number of presses of the PCIA pump by the patient on POD1 and POD2.;Total amount of sufentanil used for rescue analgesia on POD1 and POD2.;Record the occurrence of adverse events on POD1 and POD2, including the degree of nausea and vomiting, level of sedation, incidence of respiratory depression, incidence of hypotension, incidence of bradycardia, and incidence of pruritus.;Time of first flatus after surgery.;Time of first bowel movement after surgery.;Number of bowel sounds per minute at 12h, 24h, 36h, and 48h post-surgery.;QoR-15 scores of the patient at 24h and 48h post-surgery.;VAS pain satisfaction score at 48h post-surgery.; | — |
Countries
China
Contacts
Public ContactYan Wenjun
Gansu Provincial Hospital
Outcome results
None listed