obstetric antiphospholipid syndrome
Conditions
Interventions
Healthy control group:None
Sponsors
The Second Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: OAPS Group Inclusion Criteria:(1)Met the diagnostic criteria for Obstetric Antiphospholipid Syndrome (OAPS) as defined by the Chinese Society of Perinatal Medicine ;(2)Had complete medical records with maternal and neonatal outcomes confirmed through telephone follow-up. Healthy Control Group Inclusion Criteria:(1)Concurrently pregnant healthy women matched to the case group by gestational period;(2) Did not meet diagnostic criteria for either OAPS or NOAPS ;(3)No personal or family history of autoimmune disorders;(4)No usage of antibiotics, adrenocorticosteroids, immunosuppressants, or related medications during pregnancy.
Exclusion criteria
Exclusion criteria: (1) Presence of reproductive system abnormalities, such as uterine malformation, cervical incompetence, premature ovarian failure, etc.; (2) History of smoking, alcohol consumption, and drug use that significantly impacts pregnancy outcomes; (3) Fetal demise resulting from major fetal malformations and fetal chromosomal abnormalities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Multimodal ultrasound imaging results;Blood biomarkers;Measure serum, urine, and placental tissue metabolomic markers, etc.;General Clinical Data (Blood Pressure, BMI, etc.); | — |
Countries
China
Contacts
Public ContactHongXia Yu
The Second Affiliated Hospital of Zhengzhou University
Outcome results
None listed