Parkinson's disease
Conditions
Interventions
Group taVNS:Transcutaneous vagus nerve stimulation
Sham stimulation group:N/A
Sponsors
The First Affiliated Hospital of University of science and technology of China
Eligibility
Sex/Gender
All
Age
64 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Parkinson's disease patients undergoing elective DBS 2.Meets the diagnostic criteria for Parkinson's disease in China released in 2016 3. Age >=64 years old, gender not limited 4. Voluntarily participate in this experiment and sign the informed consent form 5. ASA classification: II-III level 6. Body mass index: 18.5-23.9kg/m^2
Exclusion criteria
Exclusion criteria: 1.Contraindication for taVNS: Installation of pacemakers, cochlear implants, or simultaneous use of other electrical stimulation therapies; 2.There is infection or skin damage in the stimulated area of the skin; 3.Presence of intracranial vascular lesions or space occupying lesions; 4.Patients with severe primary diseases of the heart, brain, liver, kidney, and hematopoietic system, as well as acute diseases, infectious diseases, and malignant tumors; 5.Patients with severe cognitive and mental disorders, hearing impairments, and other conditions that prevent them from cooperating; 6.Parkinson's superposition syndrome, multiple system atrophy; 7. Patients who refuse this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wake up duration;Salivary cortisol;Alpha amylase in saliva;Clock drawing test score;Agitation score during awakening period(RASS system rating); | — |
Countries
China
Contacts
Public ContactKang Fang
Southern District of the First Affiliated Hospital of University of science and technology of China
Outcome results
None listed