Disorders of consciousness, DoC
Conditions
Interventions
Research group:Trigeminal nerve stimulation
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2.The patient was assessed as vegetative state/unresponsive awakening syndrome (VS/UWS) or microconscious state (MCS) by using CRS-R; 3. Duration > 28 days; 4. No skull defect or skull repair has been performed; 5. No large open scalp wound; 6. The vital signs are stable and can be tested by EEG; 7. Guardians voluntarily sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Previous mental or neurological disease; 2. Combined with any clinically significant or unstable medical diseases, such as serious cardiopulmonary insufficiency, renal insufficiency, and difficult to control epilepsy; 3. Use of central sedative drugs during treatment; 4. Failure to complete the observer as planned due to serious complications during the study, such as termination of treatment, natural shedding (including transfer to hospital, transfer to department, refusal of treatment by family members and death); 5.The patient or his family members do not cooperate and do not sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Power spectral density,PSD; | — |
Secondary
| Measure | Time frame |
|---|---|
| Degree of improvement in Coma Recovery Scale-Modified (CRS-R) score;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactChao Ma
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed