Alzheimers disease dementia
Conditions
Interventions
surgical intervention group:Deep cervical lymphatic vessel/node-venous anastomosis
Sponsors
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. The patient or guardian signs the informed consent form; 2. Age 50~80 years old (>= 50 years old, =1 level, <=3 levels);
Exclusion criteria
Exclusion criteria: 1. There are contraindications for MRI, ICG angiography, or PET scan; 2. There are contraindications for lumbar puncture; 3. Severe heart disease or unstable hemodynamics; 4. Severe pulmonary disease, including severe obstructive, restrictive, or mixed ventilatory dysfunction, or Acute inflammation within 3 months; 5. Liver function impairment, with AST or ALT > 3 times the upper limit of normal; 6. Renal dysfunction, with GFR =4 microbleeds in the cerebral lobes; 8. History of cerebral hemorrhage or cerebral infarction with severe neurological dysfunction remaining; 9. Blood diseases, coagulation disorders, abnormal coagulation function; 10. Abnormal thyroid function; 11. Severe stenosis in intracranial or cervical vessels with residual severe neurological dysfunction; 12. Severe hypertension not effectively controlled, with systolic blood pressure >= 180mmHg or diastolic blood pressure >= 110mmHg; 13. The patient has a disease that requires systemic glucocorticoid therapy; 14. Substance abuse (including drugs, narcotics, and alcohol addiction); 15. Severe infectious diseases, including HIV positive and severe infections; 16. Severe mental illness or a potential risk of suicide; 17. Malignant tumor resection within 3 years after surgery; 18. Participated in other interventional clinical trials within the past three months; 19. The physician judged that the compliance was poor, unable to complete or unwilling to cooperate with the regular follow-up after surgery; 20. There are other circumstances that are not suitable for this clinical trial as per the physician's judgment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in scores of clinical symptom related scales;Changes in intracranial pathological protein deposition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in brain structure volume and cerebrospinal lymphatic function index;changes in plasma AD-related biomarker levels;changes in life signs;Cervical Vascular Patency Assessment;Pathological changes in the cervical lymphatic system;changes in CSF AD-related biomarker levels; | — |
Countries
China
Contacts
Public ContactYixin Zhang
Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine
Outcome results
None listed