Early-Onset Neonatal Sepsis
Conditions
Interventions
Control group (The intervention group received protocolized critical care (with standardized respiratory support) plus targeted cefoperazone-sulbactam monotherapy (3-day course), while avoiding other
Treatment group (Neonates with sepsis receiving comprehensive critical care (including respiratory support and suctioning) treated solely with cefoperazone-sulbactam (80 mg/kg q8h for 3 days) as antim
Sponsors
The Second Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
0 Days to 28 Days
Inclusion criteria
Inclusion criteria: (1)The study included term or preterm neonates aged 0–28 days; (2)Diagnosed with neonatal sepsis; (3)The antibiotic regimen consisted of intravenous cefoperazone-sulbactam (80 mg/kg per dose, 8-hourly) for 72 hours.
Exclusion criteria
Exclusion criteria: (1)Pre-existing cardiac comorbidities (congenital heart defects, severe CHF) that could confound hemodynamic assessments or exacerbate catecholamine toxicity; (2)Patients with jaundice, ALT/AST >100 U/L, or total bilirubin >300 µmol/L were excluded; (3)Neonates meeting KDIGO-AKI Stage 3 criteria (Cr >5.0 mg/dL or urine output <0.3 mL/kg/h despite fluid resuscitation) or requiring renal replacement therapy were excluded; (4)Neonates with a history of seizures at birth or severe neurodevelopmental anomalies were excluded; (5)Patients with incomplete demographic or clinical data were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Untoward effect ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters;Hematological indicators; | — |
Countries
China
Contacts
Public ContactYunfeng Zhang
The Second Hospital of Jilin University
Outcome results
None listed