Lung diseases
Conditions
Interventions
Group M:Loading dose: 4 mg (4ml). Postoperative PCA: Morphine 50 mg+ normal saline (NS) =100 ml. Compression volume: 1mg. Locking time: 6 min. Limit: 8 mg/h
Group O1:Loading dose 1.5 mg (4 ml), postoperative PCA: oxelidine 35 mg+NS=100 ml, compression volume 0.1 mg, locking time 6min, limit 2 mg/h.
Group O2:Loading dose 1.5 mg (4 ml), postoperative PCA: oxelidine 35 mg+NS=100 ml, compression amount 0.35 mg, locking time 6min, limit 2 mg/h.
Group O3:Loading dose 1.5 mg (4 ml), postoperative PCA: oxelidine 35 mg+NS=100 ml, compression amount 0.5 mg, locking time 6 min, limit 2 mg/h.
Sponsors
The Second Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1) Age 18~65 years old; 2) ASA grade I-III; 3)BMI18-30 kg/m^2; 4) Elective thoracoscopic lobectomy under general anesthesia is planned, and the subject agrees to participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1) Severe lung diseases, such as chronic obstructive pulmonary disease, pleural effusion, asthma, pneumothorax, and previous history of chest surgery, etc. 2) Preoperative blood oxygen saturation =90%; 3) Those who have experienced unstable angina pectoris, myocardial infarction or heart failure within 3 months; 4) Any cerebrovascular accident has occurred within the past three months, such as stroke, transient ischemic attack, etc. 5) Those with severe abnormal liver and kidney functions; 6) Those who are unable to communicate due to neurocognitive dysfunction or language disorders before the operation; 7) Patients who are participating in other clinical trials; 8) Those who have contraindications or allergies to the test drug or other anesthetic drugs used during the test process; 9) Those who have received long-term opioid treatment or used any analgesics within 48 hours; 10) And other circumstances that anesthesiologists consider may interfere with the research results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main efficacy evaluation index: The response rate to the test drug at each time point within 48 hours after the administration of the loading dose.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary efficacy evaluation indicators: 1. Response rate to the test drug at each time point within 1 hour after the administration of the loading dose.;Safety evaluation index;The general condition of the patient, the time of extubation after the operation, the heart rate, blood pressure and blood oxygen saturation of the patient at the time of extubation and 5 minutes and 10 minutes after extubation;The time of the patient's first ambulation and the length of hospital stay;The sleep quality scores of the patients at 24 hours, 48 hours and 72 hours after the operation;The occurrence of pulmonary complications (PPCs) within 7 days after the operation of the patients;The QoR-15 scale scores of the patients 1 day before the operation, 24 hours, 72 hours after the operation, and on the day of discharge;The satisfaction of perioperative patients with pain management; | — |
Countries
China
Contacts
Public ContactXianwen Hu
The Second Hospital of Anhui Medical University
Outcome results
None listed