ACS
Conditions
Sponsors
Qujing No.1 Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Unstable angina: (1) cTn increases or decreases after increase; (2) prolonged (>20 min) resting angina; (3) new-onset angina within 3 months, manifested as spontaneous angina pectoris or exertional angina (CCS grade II or III.); (4) Previously had stable angina, the symptoms worsened within the last 1 month, and had at least CCS grade III. characteristics (i.e., worsening angina); (5) Angina pectoris after myocardial infarction. ECG includes new-onset ST-segment depression, transient ST-segment elevation, and T-wave changes, which are dynamically altered. Coronary artery stenosis confirmed by coronary angiography. 2. Acute myocardial infarction: (1) cTn>99th upper limit of normal reference value (ULN) (at least once) accompanied by one of the following conditions: persistent ischemic chest pain; (2) STEMI: ECG showed a new ST-segment arch dorsal upward elevation with or without pathological Q wave and R wave reduction; (3) NSTEMI: ECG shows new-onset ST-segment depression or low-level and inverted T waves; (4) echocardiography showed new segmental wall activity abnormalities; (5) Coronary artery stenosis or occlusion confirmed by coronary angiography.
Exclusion criteria
Exclusion criteria: 1. Patients with coronary artery lesions confirmed by coronary angiography but cannot be diagnosed with ACS; 2. Patients with stroke, severe liver and kidney insufficiency, hematopoietic system diseases, infectious diseases, rheumatic immune system diseases, and malignant tumors with radiotherapy and chemotherapy; 3. Patients with congenital heart disease, cardiomyopathy, myocarditis, valvular heart disease, aortic dissection, acute pulmonary embolism, severe heart failure, respiratory failure, malignant arrhythmia, or secondary myocardial disease caused by any known systemic disease; 4. Patients with elevated markers of myocardial injury such as polymyositis, dermatomyositis, malnutrition, crush injury syndrome, hypothyroidism, rhabdomyolysis, etc.; 5. Patients with a history of old myocardial infarction and coronary revascularization; 6. Mentally ill, pregnant and lactating women; 7. The relevant data in the treatment process are incomplete and the clinical data are missing; 8. Patients who have not obtained informed consent; 9. Those who cannot be tested and followed up according to the test protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum Cathepsin B;NT-proBNP;Left Ventricular Ejection Fraction;Creatine Kinase MB isoenzyme;Myoglobin;High-Sensitivity Troponin I; | — |
Secondary
| Measure | Time frame |
|---|---|
| Triglycerides;Platelet;High-Density Lipoprotein;Total Cholesterol;Low-Density Lipoprotein;Red Blood Cell(s);White Blood Cell(s); | — |
Countries
China
Contacts
Public ContactShen Ting
Qujing First People 's Hospital
Outcome results
None listed