Postoperative fatigue syndrome
Conditions
Interventions
Experimental Group 1:After anesthesia induction, esketamine was intravenously administered at a loading dose of 0.5 mg/kg, followed by a maintenance dose of 4 µg/kg/min for continuous pumping.
Experimental Group 2:After anesthesia induction, esketamine was intravenously administered at a loading dose of 0.25 mg/kg, followed by a maintenance dose of 2 µg/kg/min for continuous pumping.
Control group:After anesthesia induction, the same volume of normal saline was intravenously administered.
Sponsors
Dongguan First Hospital Affiliated to Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with lung diseases and scheduled to undergo thoracoscopic lobectomy under general anesthesia; 2. Age between 18 and 65 years old; 3. ASA Grade I - II; 4. BMI 18-25kg/m^2; 5. The patients and their families voluntarily agreed to participate in this study and signed the informed consent form, and were able to understand and cooperate with the research evaluation. 6. No drugs that might affect postoperative fatigue syndrome and anesthesia quality assessment, such as opioid analgesics and sedative-hypnotic drugs, were used before the operation
Exclusion criteria
Exclusion criteria: 1.There are serious systemic diseases, such as severe cardiovascular diseases (recent myocardial infarction, severe heart failure, etc.), severe respiratory diseases (acute respiratory distress syndrome, active pulmonary tuberculosis, etc.), and severe liver and kidney dysfunction (decompensated liver cirrhosis, acute renal failure, etc.). 2. Unstable hypertension (systolic blood pressure persistently above 180mmHg or diastolic blood pressure persistently above 110mmHg); 3. Patients with uncontrolled hyperthyroidism before the operation; 4. Have a history of mental illness or neurological disorders and unstable conditions; 5. There are coagulation dysfunction diseases, such as hemophilia, disseminated intravascular coagulation (DIC), etc. 6. There was fatigue syndrome before the operation, and the Fatigue Severity Scale (FSS) score was greater than 36 points. 7. There were sleep disorders before the operation, and the Pittsburgh Sleep Quality Index (PSQI) score was greater than 5 points; 8. Cognitive dysfunction was diagnosed by CAM before the operation; 9. There are other serious diseases or conditions that may affect the research results, such as advanced malignant tumors, severe malnutrition, etc. 10. During the research process, patients are unable to receive treatment or follow-up as per the pre-determined plan for various reasons, such as being transferred to another hospital halfway or being lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative fatigue syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| The physical strength of the subjects recovered.;Sleep quality of the subjects;Subject pain score;The incidence of postoperative delirium;Incidence of adverse events during the perioperative period; | — |
Countries
China
Contacts
Public ContactXiaoZheng
Dongguan First Hospital Affiliated to Guangdong Medical University
Outcome results
None listed