Term Singleton Pregnancy
Conditions
Interventions
Hydromorphone group (experimental group) :The experimental group will receive hydromorphone at 0.2 mg/kg combined with palonosetron at 4 µg/kg, diluted with normal saline to a total volume of 150 ml.
sufentanil group (control group):The control group will receive sufentanil at 2 µg/kg combined with palonosetron at 4 µg/kg, diluted with normal saline to a total volume of 150 ml. PCIA settings: back
Sponsors
The First Affiliated Hospital of Anhui University of Science and Technology/Huainan First People's Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Term singleton pregnancy; 2.ASA physical status I–II; 3.signed informed consent; 4.and successful spinal anesthesia.
Exclusion criteria
Exclusion criteria: 1.History of opioid allergy; 2.Presence of severe pregnancy complications (e.g., eclampsia, HELLP syndrome); 3.Long-term use of analgesics before surgery; 4.Communication disorders or history of psychiatric illness; 5.Long-term preoperative use of opioids; 6.History of depression or preoperative Self-Rating Depression Scale (SDS) score >= 50; 7.History of chronic sleep disorders or preoperative Pittsburgh Sleep Quality Index (PSQI) score > 5.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting VAS score at 6 hours postoperatively;incidence of dizziness and drowsiness within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in resting and dynamic VAS scores at 2, 6, 12, 24, and 48 hours postoperatively;Ramsay sedation scores at 24 and 48 hours postoperatively;Time to first activation of the analgesia pump and total analgesic consumption from the pump;Incidence of adverse events such as nausea, vomiting, pruritus, and respiratory depression;SDS and PSQI scores at baseline (preoperative) and at 24 and 48 hours postoperatively; | — |
Countries
China
Contacts
Public ContactYuanyuan Zhao
The First Affiliated Hospital of Anhui University of Science and Technology / Huainan First People's Hospital
Outcome results
None listed