High-Risk Endometrial Cancer
Conditions
Interventions
Moderately Hypofractionated Radiotherapy Group:Moderately Hypofractionated Adaptive Postoperative Radiotherapy
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.18–70 years old; 2.ECOG score 0–2, ??expected to comply with oART procedures; 3.Primary surgery including ??total hysterectomy and bilateral salpingo-oophorectomy??, with or without pelvic/para-aortic lymph node dissection/sampling or sentinel lymph node biopsy; 4.FIGO 2009 Stage I?? (Grade 3 endometrioid adenocarcinoma with superficial myometrial invasion and extensive LVSI; Grade 2 endometrioid carcinoma with deep myometrial invasion and extensive LVSI; Grade 3 endometrioid carcinoma with deep myometrial invasion), ??Stage II–IIIC1 endometrioid carcinoma??, and ??Stage I–IIIC1 serous carcinoma or clear cell carcinoma??; 5.Patients and families fully understood the protocol and provided ??written informed consent?? prior to enrollment.
Exclusion criteria
Exclusion criteria: 1.History of abdominal or pelvic radiotherapy; 2.If no adjuvant chemotherapy, over 12 weeks between surgery and radiotherapy initiation; if combined with adjuvant chemotherapy, over 6 months between surgery and radiotherapy; 3.History of other malignant tumors; 4.Pregnant or breastfeeding women; 5.Uncontrolled active infection or fever; 6.Diagnosis of IBD (regardless of activity status); 7.Severe diseases affecting trial compliance, including: Unstable cardiac disease requiring treatment, renal impairment, chronic hepatitis, poorly controlled diabetes and psychiatric disorders;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Acute Toxicity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life;Chronic Toxicity;3-year treatment failure-free survival rate; | — |
Countries
China
Contacts
Public ContactXiaorong Hou
Peking Union Medical College Hospital
Outcome results
None listed