Postoperative nausea and vomiting
Conditions
Interventions
Ondansetron group:Patients who were randomly assigned to the ondansetron group, or those who were randomly assigned to the sham chewing group but refused or were excessively drowsy, received intraveno
Fake Chewing Group:Patients who experience PONV in PACU are randomly assigned to the sham chewing group, and the observer evaluates their alertness/sedation (OAA/S) score as 5-6 ("respond immediately
Sponsors
Jiangxi Provincial People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Female patients undergoing elective general anesthetic laparoscopic surgery and breast surgery; Age 18~65 years old; ASA Class I~III; Subjects voluntarily participate in the study and sign the informed consent form for this study.
Exclusion criteria
Exclusion criteria: Those who are allergic to opioids, benzodiazepines, propofol and other narcotic drug excipients; Suspected abuse of narcotic analgesics or sedatives, as well as alcoholics; Have severe cardiac arrhythmias; History of acute respiratory infection within 2 weeks with no cure; Those with a history of severe heart, brain, lung, liver, kidney or metabolic diseases; Have a neuromuscular system disorder (e.g., myasthenia gravis); people with mental illness; Those who predict that a difficult airway may occur or have occurred, such as modified Marhalanobis class III.-IV; Pregnant or lactating females; Use of long-acting antiemetics, emetics, opioids or glucocorticoids within one week before surgery; Have other diseases that may manifest as nausea or vomiting , such as hepatitis or gastric ulcers; Contraindications to dexamethasone; impaired pharyngeal or esophageal function; Have full upper and lower dentures (unable to chew)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of relief of PONV; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of nausea, retching, and vomiting; | — |
Countries
China
Contacts
Public ContactLuo Heguo
Jiangxi Provincial People's Hospital
Outcome results
None listed