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Construction of a Prediction Model for Post-mTBI Sequelae and Investigation of TMS Therapeutic Mechanisms Using Resting-State fMRI

Construction of a Prediction Model for Post-mTBI Sequelae and Investigation of TMS Therapeutic Mechanisms Using Resting-State fMRI

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105247
Enrollment
Unknown
Registered
2025-07-01
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

mild traumatic brain injury(mTBI)

Interventions

Experimental group:Transcranial Magnetic Stimulation(TMS)
Control group:Sham stimulation
Observation group:None

Sponsors

Ankang Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Inclusion Criteria for Developing the Prediction Model 1. Patient admitted via the emergency department. 2. Aged 18 - 65 years old. 3. Within 7 days after traumatic brain injury. 4. With a Glasgow Coma Scale (GCS) score of 13 - 15 upon presentation. 5. Loss of consciousness for less than 30 minutes and post - traumatic amnesia of less than 24 hours. Inclusion Criteria for Patients Receiving Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment: 1. Meet the diagnostic criteria for mild traumatic brain injury (mTBI). 2. Presence of post-concussion syndrome symptoms such as headache, dizziness, attention deficit, memory impairment, and emotional instability within 7 days after mTBI. 3. Symptoms lasting for more than 3 months.

Exclusion criteria

Exclusion criteria: Exclusion Criteria: 1. Contraindications to MRI. 2. Penetrating brain injury, spinal cord injury, or severe systemic injuries. 3. Pregnant or breastfeeding individuals. 4. Failure to obtain informed consent. 5. Obvious MRI artifacts and poor image quality.

Design outcomes

Primary

MeasureTime frame
MRI;Neuropsychological scales;

Countries

China

Contacts

Public ContactYanan Zhu

Ankang Central Hospital

zhuyanan1977@163.com+86 152 0915 8755

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026