oral leukoplakia
Conditions
Interventions
control group with diabetes:None
Control group without diabetes:None
Oral leukoplakia group with diabetes:None
Oral leukoplakia group without diabetes:None
Oral squamous cell carcinoma group with diabetes:None
Oral squamous cell carcinoma group without diabetes:None
Sponsors
Peking University School and Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion criteria: 1. Group of OLK patients with or without DM: (1) Fulfillment of the above diagnostic criteria for OLK with (in the group with DM) or without (in the group without DM) DM. (2) No malignant transformation had occurred. (3) No other oral mucosal diseases. (4) Patients were over 18 years of age and of either sex. (5) Have signed an informed consent to participate in the study. 2. Group of OSCC patients with or without DM: Patients who met the above diagnostic criteria for OSCC, or those who had malignant transformation of part of the OLK into OSCC, and who also met (in the group with DM) or did not meet (in the group without DM) the diagnostic criteria for DM. (2) No other oral mucosal diseases. (3) Patients were over 18 years of age and of any gender. (4) Have signed the informed consent to participate in the study. 3. Healthy controls with or without DM: (1) Fulfillment of the diagnostic criteria for DM (in the group with DM) or not (in the group without DM). (2) No oral mucosal disease. (3) Patients were over 18 years old and of either sex. (4) Have signed the informed consent form and agreed to participate in the study.
Exclusion criteria
Exclusion criteria: (1) Patients with malignant transformation of some areas of OLK into OSCC who have had surgical removal of OSCC lesions. (2) Chronic disease: patients with other serious systemic diseases (e.g., cancer, cardiovascular disease, etc.) that may affect the oral microbiota. (3) Oral disease: patients with severe periodontal disease, dental caries or other oral diseases. (4) Antibiotic use: patients who have used antibiotics or other medications that may affect the oral microbiota within the past 1 month. (5) Immune system disorders: diagnosis of immune system disorders such as systemic lupus erythematosus. (6) Other factors: pregnancy, lactating women, or any other factors that may interfere with the results of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| macro-genome ;metabolomics;viral detection; | — |
Countries
China
Contacts
Public ContactZhou Peiru
Peking University School and Hospital of Stomatology
Outcome results
None listed