postoperative analgesia
Conditions
Interventions
Test Group 1 :Preoperative active rTMS stimulation
Test Group 2:Postoperative active rTMS stimulation
Test Group 3:Preoperative or postoperative sham rTMS stimulation
Sponsors
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Hospitalized patients? aged 18 to 75 years (inclusive); 2. Scheduled for ?elective major thoracic or abdominal surgery? under general anesthesia with anticipated duration of 1-4 hours; 3. Absence of ?preoperative pain? at the intended surgical site; 4. ?ASA physical status classification: Class I-III; 5. Provision of signed ?informed consent form.
Exclusion criteria
Exclusion criteria: 1. Pre-existing ?major comorbidities? (e.g., severe cardiopulmonary insufficiency, advanced malignancy with ?anticipated life expectancy <90 days); 2. Preoperative ?major organ failure? or ?uncontrolled asthma?; 3. History of ?seizure disorders, family history of epilepsy, ?neurosurgical history, or documented ?intracranial neoplasms; ?4. Substance use disorder? within 6 months prior to screening; 5. ?Pregnancy, lactation, or parturient women; ?6. Declined participation? or ?cognitive impairment? preventing pain assessment/questionnaire completion; Current enrollment in other ?interventional clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS Pain Score Scale;Medication Usage in Patient-Controlled Analgesia (PCA); | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory Cytokine Levels;Perceived Stress Scale (PSS Scale);Hospital Anxiety and Depression Scale (HADS);Quality of Recovery-15 Self-Rating Scale (QoR-15 Scale);Incidence of Surgery- and Anesthesia-Related Complications; | — |
Countries
China
Contacts
Public ContactLiqun Yang
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed