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Exploring and precisely applying the clinical cardiovascular potential risks of zoledronic acid versus denosumab based on regional healthcare big data

Exploring and precisely applying the clinical cardiovascular potential risks of zoledronic acid versus denosumab based on regional healthcare big data

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500105212
Enrollment
Unknown
Registered
2025-06-30
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis

Interventions

Osteoporosis (Zoledronic acid):None
Osteoporosis (Denosumab):None

Sponsors

Affiliated Kunshan Hospital of Jiangsu University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to No maximum

Inclusion criteria

Inclusion criteria: 1.Age 50 or older. 2.diagnosed with osteoporosis. 3.patients receiving anti-osteoporosis medication treatment (zoledronic acid and denosumab) at a hospital. 4. Have identity information for matching and follow-up.

Exclusion criteria

Exclusion criteria: 1. Changed treatment plans during follow-up due to various reasons after using zoledronic acid or denosumab (e.g., using zoledronic acid first and denosumab second). 2. The patient was recorded only once for using either zoledronic acid or denosumab, and subsequent visit information could not be registered by the region. 3. The patient has a history of tumors or related vascular diseases. 4. Previous history of atrial fibrillation and stroke 5. Patients with malignant tumors 6. Renal insufficiency 7. Autoimmune diseases 8. Previous diagnosis of atrial fibrillation (or stroke) 9. Taking anti-arrhythmic drugs

Design outcomes

Primary

MeasureTime frame
Zoledronic acid injection;Denosumab injection;

Countries

China

Contacts

Public ContactLu ke

Department of Orthopedics, Affiliated Kunshan Hospital of Jiangsu University

sgu8434@sina.com+86 150 5027 4780

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026