Postoperative acute respiratory distress syndrome
Conditions
Interventions
SGB group:A left-sided stellate ganglion block will be performed preoperatively using 5 mL of a mixed solution containing 0.375% ropivacaine and 0.5% lidocaine.
Control group:A left-sided stellate ganglion block will be performed preoperatively using 5 mL of normal saline.
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age > 18 years; 2.ASA physical status classification I to III; 3.Elective open cardiac valve or coronary artery surgery under cardiopulmonary bypass (CPB); 4.Voluntarily signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Body mass index (BMI) >= 30 kg/m^2; 2.Preoperative pulse oxygen saturation < 95%; 3.Left ventricular dysfunction; 4.Procedures involving deep hypothermic circulatory arrest; 5.Infective endocarditis or evidence of other active infections; 6.History of cardiac or pulmonary surgery; 7.Comorbid chronic pulmonary diseases, including COPD, pulmonary fibrosis, asthma, etc.; 8.Pulmonary infection or sepsis within 1 month before surgery; 9.Moderate to severe anemia prior to surgery; 10.Preoperative liver cirrhosis; 11.Neuromuscular disorders (e.g., thymoma, myasthenia gravis, myopathy, muscular dystrophy); 12.Allergy to local anesthetics; 13.Infection at the puncture site; 14.Coagulopathy; 15.Contralateral phrenic nerve or recurrent laryngeal nerve paralysis; 16.Glaucoma; 17.Psychiatric disorders that affect cooperation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index at 24 h postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of postoperative mechanical ventilation;Postoperative systemic immune-inflammation index (SII);Postoperative neutrophil-to-lymphocyte ratio (NLR);Incidence of postoperative pulmonary complications;Postoperative hemoglobin level;Postoperative SOFA score;Incidence of postoperative delirium;Incidence of postoperative sleep disturbances;Postoperative nausea and vomiting (PONV) score;Postoperative pain score;Incidence of postoperative acute respiratory distress syndrome (ARDS);Incidence of postoperative arrhythmia;Incidence of postoperative mechanical circulatory support (MCS) use;Dosage of postoperative vasoactive medications;Incidence of postoperative hepatic and renal injury;Postoperative ICU length of stay;Length of hospital stay after surgery;Postoperative Quality of Recovery-15 (QoR-15) score; | — |
Countries
China
Contacts
Public ContactJiafeng Wang
Shanghai Changhai Hospital
Outcome results
None listed