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Study on the Effects of opioid-free anesthesia combined with lidocaine and esketamine and traditional anesthesia methods on the incidence of perioperative respiratory complications in Children: A randomized controlled trial

Study on the Effects of opioid-free anesthesia combined with lidocaine and esketamine and traditional anesthesia methods on the incidence of perioperative respiratory complications in Children: A randomized controlled trial

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105161
Enrollment
Unknown
Registered
2025-06-30
Start date
2025-06-30
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Perioperative respiratory system complications

Interventions

Opioid group:Sufentanil at 0.25ug/kg and normal saline were intravenously injected at the same rate, and tramadol at 1mg/kg and ibuprofen at 10mg/kg were continuously pumped until the end of the surge
Non-opioid group:Lidocaine at 1.0mg/kg and esketamine at 0.2mg/kg were intravenously injected and continuously pumped at 2mg/kg·h until the end of the surgery

Sponsors

Yichang Central People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 6 Years

Inclusion criteria

Inclusion criteria: 1) Age: 1-6 years old; 2) ASA Grade I or II; 3) BMI: 14-23.9kg/m^2.

Exclusion criteria

Exclusion criteria: 1) No informed consent 2) Other surgeries are performed simultaneously during hospitalization 3) There are comorbidities or ASA grade II or above 4) Long-term use of any type of medication

Design outcomes

Primary

MeasureTime frame
Perioperative Adverse respiratory Events (PRAE);

Secondary

MeasureTime frame
Postoperative pain;Postoperative delirium;Hemodynamics at baseline and 5 minutes after intubation;Yale Preoperative Anxiety Scale (mYPAS) score;

Countries

China

Contacts

Public ContactYuan Gong

Yichang Central People's Hospital

gy-yc@163.com+86 139 8674 6821

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026