Sepsis
Conditions
Interventions
Sepsis Non-immunosuppression Group:None
Sepsis Immunosuppression Group:None
Healthy Control Group:None
Sponsors
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Healthy volunteers and patients diagnosed with sepsis after ICU admission;
Exclusion criteria
Exclusion criteria: 1. Age < 18 years old; 2. Patients with immunosuppressive conditions, including malignancy, organ transplantation, acquired immunodeficiency syndrome (AIDS), autoimmune diseases, or those who received immunosuppressive agents within the past month; 3. Patients with long-term chronic infectious diseases; 4. Pregnant or lactating women; 5. Refusal to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Absolute expression of NLRC3 (copies/µL) differed between the sepsis immunosuppressed group, the sepsis non-immunosuppressed group, and healthy people; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of NLRC3 expression with immunosuppressive markers;Correlation between NLRC3 expression levels and evolution of immune status on days 1, 3, and 7 of the sepsis course;Dynamic change in Sepsis Organ Failure Score (SOFA) on days 1, 3, 7 of the course of sepsis;Incidence of nosocomial secondary infections;Time on mechanical ventilation, total length of hospital stay, length of ICU stay within 28 days of diagnosis of sepsis;Case fatality rate at 28 days after diagnosis of sepsis; | — |
Countries
China
Contacts
Public ContactJiqian Xu
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed