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Study on the Effects and Mechanisms of KOAPT Therapy for Osteoarthritis Under Mechanical Stimulation

Study on the Effects and Mechanisms of KOAPT Therapy for Osteoarthritis Under Mechanical Stimulation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105151
Enrollment
Unknown
Registered
2025-06-30
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary osteoarthritis of the knee

Interventions

KOAPT group:KOAPT exercise
Walking exercise training group:Get walking training

Sponsors

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Voluntary participation and written informed consent; 2.undertake to comply with research procedures and cooperate with the implementation of the whole process of research; 3.Age >=45 years old, gender unlimited; 4. According to the classification of osteoarthritis, at least one knee has primary knee osteoarthritis; 5.The patient is generally in good condition, without serious complications such as organ and blood system diseases; 6. During the trial, patients used smart phones and wechat apps and were willing to answer calls in time;

Exclusion criteria

Exclusion criteria: 1. A body mass index of 36kg/m^2 or above; 2. Combined with serious cardiovascular and cerebrovascular, respiratory, digestive, urinary, nervous, hematopoietic, endocrine and other primary diseases (such as unstable angina pectoris, COPD, severe osteoporosis, uncontrolled hypertension, defined as systolic blood pressure >150mmHg or diastolic blood pressure >100mmHg), As well as a history of alcohol or drug abuse, mental illness; 3.Arthritis caused by traumatic arthritis, infectious arthritis, rheumatoid arthritis, neurotrophic arthritis, avascular necrosis of bone, gouty arthritis, dermatomyositis, psoriatic arthritis, ankylosing spondylitis, systemic lupus erythematosus and other causes; 4. There are obvious motor system diseases and affect normal walking. 5.Have a history of surgery affecting daily functional activities such as heart stents and organ operations, or have a surgical plan within the future study period; 6.History of knee drug injection within 3 months; 7. Those who require/take other lower limb physical therapy and rehabilitation treatment; 8.Patients who had participated in other clinical studies within 4 weeks prior to enrollment; 9.Patients who do not accept the randomly assigned treatment plan and do not comply with the doctor's advice; 10. Patients deemed unsuitable for inclusion in this study by the study physician.

Design outcomes

Primary

MeasureTime frame
Oxford knee assessment;At the start of the clinical trial;

Secondary

MeasureTime frame
Oxford gait analysis;Plain X-ray of knee joint;30s sitting-erect test;6 minutes walking distance test;

Countries

China

Contacts

Public ContactGuohui Liu

Union Hospital, Tongji Medical College, Huazhong University of Science and Technology

liuguohui@hust.edu.cn+86 27 85726114

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026