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A Randomized, Double-blind, Placebo-controlled Trial on the Efficacy and Safety of Qinshen Mouthwash in Alleviating Periodontitis

A Randomized, Double-blind, Placebo-controlled Trial on the Efficacy and Safety of Qinshen Mouthwash in Alleviating Periodontitis

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500105147
Enrollment
Unknown
Registered
2025-06-30
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Interventions

Intervention Group: Conventional periodontal therapy, routine tooth brushing, and gargling with Qinshen mouthwash.
Control Group:Conventional periodontal therapy, routine tooth brushing, and placebo mouthwash.

Sponsors

West China Hospital of Stomatology, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-70 years old, gender is not limited; 2. Diagnosed with stage I./II grade A/B periodontitis according to the 2018 new classification of periodontal disease; 3. At least 20 natural teeth are present in the mouth, and Ramfjord index teeth (i.e., 16 teeth, 21 teeth, 24 teeth, 36 teeth, 41 teeth, 44 teeth) are natural teeth, no missing and non-residual roots; 4. Have good vision, limb movement and judgment ability, and voluntarily participate in the trial and sign the informed consent form, and be able to cooperate with the completion of the trial.

Exclusion criteria

Exclusion criteria: 1. Those who have a history of self-reported allergies to any of the ingredients used in this trial; 2. Pregnant and lactating women; 3. Those who have undergone periodontal treatment such as cleaning and scaling in the past 3 months; 4. Those who have used hormones, antibiotics and other drugs in the past 14 days; 5. Patients with liver impairment or renal insufficiency; 6. Abnormal thyroid function, blood diseases, acute viral stomatitis, traumatic ulcers, nervous system diseases, psychiatric diseases, etc.; 7. Participated in other clinical trials at the same time and did not meet the clinical endpoints, or participated in other clinical trials in the past 3 months; 8. Those who are unable to complete or cooperate with the test process. 9. Other situations that are considered by the investigator to be unsuitable for inclusion in clinical studies.

Design outcomes

Primary

MeasureTime frame
Bleeding on probing (BOP);

Secondary

MeasureTime frame
Probing Pocket Depth (PPD);Gingivitis Index (GI);

Countries

China

Contacts

Public ContactXian Liu

West China Hospital of Stomatology, Sichuan University

jssyliuxian@163.com+86 138 8076 0220

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026