Hip fracture
Conditions
Interventions
Bupivacaine liposome group: Fascia Iliaca block using bupivacaine liposomes
Ropivacaine injection group:Fascia block using ropivacaine injection
Conventional intervention group:No fascial barrier
Sponsors
Central Hospital Affiliated to Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: (1) Age >= 18 years old; (2) ASA classification Grade ?–?; (3) Scheduled for spinal anesthesia; (4) Unilateral hip fracture; (5) Elective surgery planned within 72 hours of admission; (6) Voluntarily signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Presence of fractures in other locations; (2) History of myocardial infarction or unstable angina within 6 months prior to randomization, or history of severe arrhythmias such as second-degree or higher atrioventricular block, or history of NYHA Class II or higher heart function; (3) Hepatic insufficiency (serum bilirubin exceeding 34 µmol/L); (4) Renal insufficiency (estimated glomerular filtration rate [eGFR] =1.5) or use of anticoagulants (excluding aspirin); (8) International Normalized Ratio [INR] >=1.7; (9) Infection, deformity, or skin damage at the puncture site for combined spinal-epidural or nerve block; (10) History of allergy to local anesthetics (liposomal bupivacaine or bupivacaine hydrochloride); (11) History of dementia or psychiatric disorders, or inability or unwillingness to cooperate in completing the relevant trial procedures; (12) Presence of contraindications to the experimental drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| After the patient entered the operating room, he performed intra-spinal anesthesia and placed the lateral position (T4) NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| After the patient is admitted to the hospital and enters the operating room, the accumulated dose of analgesic drugs during this period;Three groups of patients were admitted to the hospital(T1)2 hours after nerve block(T2)After entering the room(T3)Finished(T5)Postoperatively24h(T6)Postoperatively24h(T7)NRS score and improved Bromage score in patients' resting and exercise states, and the scoring curve is drawn based on the scoring results.;Subjects' satisfaction score for analgesic treatment;Surgeon satisfaction score for analgesic treatment; | — |
Countries
China
Contacts
Public ContactPeikun Han
Central Hospital Affiliated to Shandong First Medical University
Outcome results
None listed