Post-spinal anesthesia hypotension
Conditions
Interventions
Norepinephrine Group:Prophylactic application of norepinephrine
Metaraminol Group:Prophylactic application of metaraminol
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Undergo elective cesarean section under combined spinal-epidural anesthesia; 2.Age between 18 and 45 years old; 3.Singleton pregnancy at term; 4.The American Society of Anesthesiologists (ASA) physical status classification is Grade I-II.
Exclusion criteria
Exclusion criteria: 1.History of chronic hypertension or hypertensive disorders during pregnancy; 2.Those who cannot undergo intraspinal anesthesia due to contraindications; 3.Abnormal fetal development; 4.Known allergy to norepinephrine or metaraminol; 5.Refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The ED50 of prophylactic norepinephrine bolus for preventing hypotension after combined spinal - epidural anesthesia;The ED50 of prophylactic metaraminol bolus for preventing hypotension after combined spinal - epidural anesthesia; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence rates of hypotension, hypertension, nausea and vomiting, and bradycardia;The Apgar scores of the newborns at 1 minute, 5 minutes and 10 minutes;Umbilical artery blood gas analysis;Changes in hemodynamic data (systolic blood pressure (SBP), heart rate (HR), cardiac output (CO), stroke volume (SV), systemic vascular resistance (SVR));The time interval from the intrathecal injection of ropivacaine to the delivery of the fetus; | — |
Countries
China
Contacts
Public ContactXu Guanghong/Chen Xixi
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed