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The Therapeutic Efficacy of Yttrium-90 Radioembolization Versus External Beam Radiotherapy Combined with TACE for Intermediate-advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

The Therapeutic Efficacy of Yttrium-90 Radioembolization Versus External Beam Radiotherapy Combined with TACE for Intermediate-advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500105123
Enrollment
Unknown
Registered
2025-06-30
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma (HCC)

Interventions

Observation group:None

Sponsors

The First Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1.Patients aged 18-85 years; 2.Patients who strictly met the clinical diagnostic criteria for HCC or were definitively diagnosed with HCC through histopathological or cytological examination; 3.Availability of well-preserved histopathological slides with definitive pathological classification; 4.Histologically confirmed or radiologically diagnosed presence of portal vein tumor thrombus; 5.Has not received systemic treatment or surgical treatment for HCC before. 6.Child-Pugh class A or B liver function classification.

Exclusion criteria

Exclusion criteria: 1. Other primary malignant tumors outside the liver are present or accompanied by the medical history; 2. The tumor involves more than 70% of the liver parenchyma; 3. Prior systemic or local therapy, including surgery, radiotherapy, TACE, HAIC, radiofrequency ablation, percutaneous ethanol injection, and cryoablation; 4. Presence of clinically relevant ascites with a Child-Pugh ascites score of 3; 5. Unable to obtain histological sections; 6. Presence of other organ diseases; 7. Inability to obtain sufficient follow-up data without cooperation during the follow-up period.

Design outcomes

Primary

MeasureTime frame
Conversion rate of the period;Success rate of schedule delay reduction;

Secondary

MeasureTime frame
Disease control rate, DCR;Objective response rate, ORR;

Countries

China

Contacts

Public ContactXin Zheng

The First Affiliated Hospital of Xi'an Jiaotong University

zhengxin@xjtufh.edu.cn+86 29 85323215

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026